FeoA and FeoC Are Essential Components of the Vibrio cholerae Ferrous Iron Uptake System, and FeoC Interacts with FeoB
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چکیده
منابع مشابه
Vibrio cholerae FeoA, FeoB, and FeoC Interact To Form a Complex.
UNLABELLED Feo is the major ferrous iron transport system in prokaryotes. Despite having been discovered over 25 years ago and found to be widely distributed among bacteria, Feo is poorly understood, as its structure and mechanism of iron transport have not been determined. The feo operon in Vibrio cholerae is made up of three genes, encoding the FeoA, FeoB, and FeoC proteins, which are all req...
متن کاملThe FeoC protein leads to high cellular levels of the Fe(II) transporter FeoB by preventing FtsH protease regulation of FeoB in Salmonella enterica.
In the gammaproteobacteria, the FeoA, FeoB, and FeoC proteins constitute the Feo system, which mediates ferrous iron [Fe(II)] import. Of these Feo proteins, FeoB is an inner membrane Fe(II) transporter that is aided by the small protein FeoA. However, the role of another small protein, FeoC, has remained unknown. Here we report that the FeoC protein is necessary for FeoB protein-mediated Fe(II)...
متن کاملLon-mediated proteolysis of the FeoC protein prevents Salmonella enterica from accumulating the Fe(II) transporter FeoB under high-oxygen conditions.
The Salmonella Feo system consists of the FeoA, FeoB, and FeoC proteins and mediates ferrous iron [Fe(II)] import. FeoB is an inner membrane protein that, along with contributions from two small hydrophilic proteins, FeoA and FeoC, transports Fe(II). We previously reported that FeoC binds to and protects the FeoB transporter from FtsH-mediated proteolysis. In the present study, we report proteo...
متن کامل1 FeoC from Klebsiella pneumoniae contains a [ 4 Fe - 4 S ] 2 cluster
19 Iron is essential for pathogen survival, virulence, and colonization. Feo is suggested to function as 20 the ferrous iron (Fe) transporter. The enterobacterial Feo system is composed of 3 proteins: FeoB is 21 the indispensable component and is a large membrane protein likely to function as a permease; FeoA is 22 a small src-homology 3 (SH3) domain protein that interacts with FeoB; FeoC is a ...
متن کاملFeoC from Klebsiella pneumoniae contains a [4Fe-4S] cluster.
Iron is essential for pathogen survival, virulence, and colonization. Feo is suggested to function as the ferrous iron (Fe(2+)) transporter. The enterobacterial Feo system is composed of 3 proteins: FeoB is the indispensable component and is a large membrane protein likely to function as a permease; FeoA is a small Src homology 3 (SH3) domain protein that interacts with FeoB; FeoC is a winged-h...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2013
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.00738-13